Since all individuals secret amyloidogenic IAPP but only some of them develop type 2 diabetes, an imbalance in the proIAPP:IAPP ratio within the secretory granules may be a very important feature in the pathogenesis of the disease [24], and prolonged hyperglycemia may lead to a higher proportion of unprocessed proIAPP [25]. This evidence concerns the gene IAPP and Hyperglycemia.