STAT3 and colorectal carcinoma: Similarly, suppression of IL-6-induced phospho-STAT3(Tyr705) and truncation of gp130 by MEDICA were abrogated in CRC HT29 cells infected with shB-Raf(V600E) (Figure 3E), or by inhibiting MEK activity by either U0126 or PD325901 (Figure 3F).