Also, suppression of EGF-activated phospho-EGFR(Tyr1068), phospho-Akt(Ser473) and phospho-Erk(Tyr204) by MEDICA was abrogated in CRC HT29 cells infected with shB-Raf(V600E) (Figure 3C), or by inhibiting MEK activity by added U0126 (Figure 3D). Here, AKT1 is linked to colorectal carcinoma.