The Cell Miner database (http://discover.nci.nih.gov/cellminer/) information on the breast cancer cell lines showed that WRN expression was low in two of the CPT-sensitive cell lines (MCF-7 and T47D), high in one CPT-resistant cell line (BT-549) and low in another CPT-resistant (MDA-MB-231) cell line (Figure 5a). The gene discussed is WRN; the disease is breast cancer.