Because radiotherapy has been shown to increase the vascularity and invasiveness of surviving EMT-like radioresistant cancer cells, the brain's specific response to silibinin-induced STAT3 blockade might reflect the inhibition of radiation-induced progression (or pseudoprogression) of intracranial lesions in comparison to non-irradiated, STAT3-independent extracranial ones [36–40]. Here, STAT3 is linked to cancer.