Mutated ASXL1, reported as a negative survival factor in numerous studies of heterogeneous MDS cohorts undergoing unspecified therapies [8-10, 14], was associated with shorter survival in a study by Traina et al, evaluating an azacitidine treated cohort (n=92, of which around 40 were higher-risk MDS), but had no impact on survival in a larger cohort undergoing hypomethylating agent (HMA) therapy (n=213, of which 113 were higher-risk MDS) [19, 20]. This evidence concerns the gene ASXL1 and myelodysplastic syndrome.