TPO and Thrombocytopenia: However, only in vivo treatment may answer this question since TPO mimetics such as Romiplostim or Elthrombopag lead to substantial increased platelets in immune thrombocytopenia such as idiopathic thrombocytopenic purpura (ITP) or other cancer-related thrombocytopenia, even when a MK apoptosis is part of the mechanism of the thrombocytopenia [22, 23].