AKT1 and cancer: In parallel, since in different cancer cells Mcl-1 is induced by Akt and STAT-3 intracellular pathways [33-35], which are implicated in B-CLL pathogenesis [12, 36-39], we have investigated the potential involvement of Akt and STAT-3 in the anti-leukemic activity of Met-DCA cocrystal.