In the present study, our results focused on perioperative treatment with flurbiprofen significantly up-regulated the postoperative percentages of CD1c+ mDCs, CD141+ mDCs and CD123+ pDCs, as well as anti-tumor cytokine profile, but this short-term increase of the postoperative naturally circulating DCs subsets in flurbiprofen-treated patients didn't last for post-OP 48h. This evidence concerns the gene CD1C and neoplasm.