A growing amount of information supports that tumor-derived PGE2 specifically exerts a suppressive effect on DCs biology through a paracrine and/or autocrine manner, which reduces the maturation of DCs and their expression of MHC class II molecules, ability to present TAAs and prime anti-tumor T cells, possibly via enhancing the production of immunosuppressive IL-10 [21–23]. This evidence concerns the gene IL10 and neoplasm.