SHP-1(PTPN6) was first identified in hematopoietic cells and is implicated in various hematopoietic signaling processes, such as integration of immunoreceptor tyrosine-based activation motif (ITAM)-mediated inhibitory signal, [32] B-cell development and function, [33] and anti-tumor function of natural killer (NK) cells. This evidence concerns the gene PTPN6 and neoplasm.