PTGS2 and esophageal squamous cell carcinoma: Firstly, the predicted binding sites of hsa-miR-26a and hsa-miR-144 in the 3′-UTR of COX2 mRNA is shown according to computational prediction, from which the luciferase reporters containing mutant binding sites were constructed (Figure 4A), to verify whether COX-2 is a direct target of miR-26a or miR-144 in human ESCC.