TNNI3 and ischemia: History ofdiabetes, CAD, lower creatinine clearance and ejection fraction were more frequentlyfound in patients with moderate-to-severe ischemia.16 Other studies demonstrating cTnI release inindividuals with heart failure31submitted to exercise or in marathon runners with exercise-induced high bloodpressure32 could alsoindicate a role for the presence of those markers in different left ventricularoverload situations.