Relationships were examined between STAT5b activity status and the expression of lipogenic transcriptional regulators that were previously investigated in STAT5a/b-null and STAT5b-null mouse studies and thought to provide key links between perturbations of STAT5b function and increases in liver steatosis, notably Pparg, Srebp1, Srebp2, Lxra, and Lxrb. Biosets were identified in which the transcription factor gene exhibited statistically significant changes in expression (|fold-change| ≥ 1.5). Here, SREBF2 is linked to fatty liver disease.