In line with this, injection of humanized mice with either TGN1412 or OKT3 in anti-human TNF-α mAb pre-treated mice both resulted in lymphopenia 4–6 hours after antibody application (Fig 5E) as already described for TGN1412 or OKT3 injection alone (compare Fig 2A). The gene discussed is TNF; the disease is lymphopenia.