MTOR and neoplasm: Lower levels of gut microbiome-associated metabolites and compounds absorbed from the diet: pipecolate, hippurate, catechol sulfate, stachydrine, ergothioneine and indolepropionate, were detected with everolimus treated obese and lean mice (p < 0.05), which could explain how mTOR suppression had systemic effects through alteration of the composition of circulating nutrients in tumor tissues (Figure 7C).