Interestingly, downregulation of p-AKT by treatment with CB was always accompanied with the same trend reduction of p-4EBP1 and MCL-1 but not p-GSK-3β, suggesting CB-induced AKT/mTOR apoptotic signaling in NSCLC cells (Figure 6C) [55–59]. The gene discussed is MCL1; the disease is non-small cell lung carcinoma.