EGFR and lung large cell carcinoma: To determine whether CB effectively inhibits the growth of human NSCLC cells, we selected four NSCLC cell lines, including A549 (lung adenocarcinoma), H1299 (lung adenocarcinoma), H460 (lung large cell carcinoma), and SK-MES-1 (lung squamous cell carcinoma), which harbor different genetic mutations involved in diverse signaling pathways, such as EGFR, RAF, and mTOR signaling pathways.