In the present study, we used 4 NSCLC cell lines (A549, H1299, H460, and SK-MES-1) that are harboring different genetic mutations in EGFR, TP53, KRAS, NRAS, PIK3CA, STK11, CDKN2A, etc. Thus, CB-induced intrinsic mitochondrial apoptosis as well as cell cycle arrest may occur through those key signaling pathways in NSCLC cells. This evidence concerns the gene PIK3CA and non-small cell lung carcinoma.