In the present study, we found that CB markedly induces apoptosis with an increase of BAX but a decrease of BCL-2, BCL-XL, and MCL-1 in NSCLC cells in a dose-dependent manner, suggesting that CB-induced apoptosis occurs through the intrinsic mitochondrial apoptosis pathway in NSCLC cells. This evidence concerns the gene BCL2L1 and non-small cell lung carcinoma.