CYCS and osteosarcoma: Likewise, recent studies reported that CB induces apoptosis through a sequence of apoptotic modulators, including an increase of BAX, cytochrome C and caspase 3 and 9 in prostate cancer cells [19, 23], BAX/BCL-2 ratio in hepatocellular carcinoma cells [47], and BAX and cleaved-PARP in osteosarcoma cells [24], but a decrease of MCL-1 in several human cancer cell lines [48].