Also known as AML1 protein or core-binding factor subunit α-2 (CBFA2), RUNX1 is located at chromosome 21 and is frequently translocated with the ETO/MTG8/RUNX1T1 gene located on chromosome 8q22, creating a fusion protein AML-ETO or t(8;21)(q22;q22) AML [38]. The gene discussed is RUNX1T1; the disease is acute myeloid leukemia.