The largest randomized, phase III clinical trial in FLT3-mutated AML conduced to date was recently presented at the 2015 American Society of Hematology (ASH) Plenary session showing the benefit of midostaurin added to induction chemotherapy (RATIFY trial) in which patients receiving midostaurin had significantly longer median OS than those receiving placebo: 74.7 versus 25.6 months (p = 0.0076) [94]. This evidence concerns the gene FLT3 and acute myeloid leukemia.