Favorable prognosis is associated with acute promyelocytic leukemia (APL) t(15;17)(q22;q12), balanced abnormalities of t(8;21)(q22;q22), inv(16)(p13.1q22), t(16;16)(p13.1;q22), mutated NPM1 without FLT3-ITD and biallelic mutated CEBPA. Intermediate 1 includes mutated NPM1 with FLT3-ITD, wild-type NPM1 with or without FLT3-ITD. Here, NPM1 is linked to acute promyelocytic leukemia.