SIRT1 and colorectal carcinoma: We showed that resveratrol inhibited the proliferation, invasion and metastasis of CRC cells (HCT116 and SW480) in 3D-alginate cultures, and this was blocked by knockdown of Sirt1 by using ASO, suggesting that Sirt1 suppression on mRNA levels is not reversible by resveratrol, highlighting the crucial role of this enzyme.