SIRT1 and colorectal carcinoma: Immunoprecipitates from CRC cells in untreated controls and Sirt1-SO/resveratrol-treated cultures, but not from Sirt1-ASO/resveratrol-treated cultures, revealed inhibition or marginal co-immunoprecipitation of acetylated and phosphorylated NF-κB subunits (p50/p65) (Figure 6B).