SIRT1 and colorectal carcinoma: In contrast, in the presence of Sirt1-ASO or co-treatment with resveratrol and Sirt1-ASO, the CRC cells underwent ultrastructural changes with highly metastatic signs, e.g., the development of microvilli on nearly the entire surface of the cells and microfilaments, indicating that the inhibition effects of resveratrol on CRC cell migration and proliferation are dependent on Sirt1.