Furthermore, it has been recently shown that resveratrol suppresses the proliferation and growth of gastric cancer cells in a Sirt1-dependent manner in vitro and in vivo [68]; however, we have shown in this report for the first time the inhibition of CRC cell proliferation through the resveratrol/Sirt1 pathway in 3D alginate cultures. Here, SIRT1 is linked to colorectal carcinoma.