SIRT1 and colorectal carcinoma: Furthermore, transfection with Sirt1-ASO, but not with control Sirt1-SO (Figure 4A,B), inhibited resveratrol-induced suppression of Ki-67 expression in both CRC cell lines, indicating that Sirt1 is one of the main targeting proteins by resveratrol during resveratrol-anti-proliferative effects in CRC cells.