In contrast, transfection with Sirt1-ASO (Figure 5A,B) significantly inhibited resveratrol-induced upregulation of Sirt1 expression in both CRC cell lines, indicating that Sirt1 is one of the main target proteins by resveratrol during the resveratrol-anti-tumor effect in CRC cells. The gene discussed is SIRT1; the disease is neoplasm.