Taken together, these findings indicate that downregulation of Sirt1 with specific ASO knocked down Sirt1 protein levels and Sirt1-NF-κB complex formation during tumorigenesis in alginate cultures (Figure 6A,B), and this blocked the ability of resveratrol to deacetylate and phosphorylate NF-κB, which may, at least in part, inhibit resveratrol-promoting anti-tumorigenic effects in CRC cells. Here, SIRT1 is linked to colorectal carcinoma.