Moreover, several lines of evidence have shown that the transcription factor, nuclear factor-kappa B (NF-κB), is a critical determinant, as it regulates a variety of pathophysiological processes, such as inflammation, cell survival, proliferation, invasion, apoptosis, differentiation and chemoresistance in different tumor cells, including CRC [7,8]. This evidence concerns the gene NFKB1 and colorectal carcinoma.