6-OHM is highly unstable and ultimately the isoform CYP1A2 of the cytochrome P450, which exactly catalyzes hydroxylation at position 6′ of MLT, is strongly upregulated in many human cancers, such as breast cancer and not only, where you can have a rate of expression greater than 200-fold compared to healthy tissue [185,186]. The gene discussed is CYP1A2; the disease is cancer.