As shown by Prior S. et al., a deregulated and abnormal mitochondrial function can induce a strong hypoxic state, regardless of the pO2 in various models of breast and prostate cancer, inducing and maintaining through this mechanism the synthesis and stabilization of HIF-1α, a phenomenon which is in accordance with other studies and previous data, and that, according to the group of Higuchi, is related to the concentration of the mtDNA [124]. This evidence concerns the gene HIF1A and prostate cancer.