Recent analysis using ZIP12 KO rats showed that ZIP12 regulates the pulmonary vascular response to chronic hypoxia [113], while ZIP13 mutations have been shown to cause the spondylocheiro dysplastic form of Ehlers–Danlos syndrome (SCD-EDS) [114,115], which is characterized by hard and connective tissue abnormalities. The gene discussed is SLC39A13; the disease is Ehlers-Danlos syndrome.