Nonsynonymous ZnT8 SNPs (rs13266634, resulting in R325W substitution) are known to increase the risk of type 2 diabetes [137,138,139,140], which is attributed to the lower zinc transport activity of the risk allele although the precise molecular mechanism of this requires further investigation because Znt8 KO mice phenotypes have been variable in sex and genetic background [2,141]. Here, SLC30A10 is linked to type 2 diabetes mellitus.