Recent analysis using ZIP12 KO rats showed that ZIP12 regulates the pulmonary vascular response to chronic hypoxia [113], while ZIP13 mutations have been shown to cause the spondylocheiro dysplastic form of Ehlers–Danlos syndrome (SCD-EDS) [114,115], which is characterized by hard and connective tissue abnormalities. Here, SLC39A12 is linked to Ehlers-Danlos syndrome.