The prevalence of FTD is 15 per 100,000 in subjects between 45 and 65 years old with mean survival rate from three to 10 years from diagnosis [133]; and it is known that 40% of FTD cases are familial [134], and 10–30% of the familial FTD patients have a mutation in the microtubule-associated protein tau (MAPT) gene [135]. This evidence concerns the gene MAPT and frontotemporal dementia.