ERBB2 and breast cancer: In a clinically relevant transgenic animal model of breast cancer in MMTV-neu mice, treatment with withaferin-A failed to alter the incidence and multiplicity of mammary tumors, but resulted in a 50% inhibition in the weight of palpable tumors and a 95.14% decrease in the mean area of microscopic invasive carcinoma as compared to the control group [21].