The induction of apoptosis in human head and neck carcinoma (MC3 and HN22) cells by withaferin-A was accompanied by upregulation of Bim, truncated Bid (t-Bid), cleavage of caspase-8, -3 and poly ADP ribose polymerase (PARP), and the elevated expression of DR5, suggesting an extrinsic pathway of apoptosis induction by this compound [67]. The gene discussed is BID; the disease is head and neck carcinoma.