VIM and soft tissue sarcoma: Withaferin-A reduced the viability of soft tissue sarcoma cells, such as that of fibrosarcoma (HT1080), leiomyosarcoma (SKLMS1), STLS26T, and high grade pleomorphic sarcoma/liposarcoma through caspase-mediated degradation of vimentin, downregulation of Akt phosphorylation and the NF-κB (p65) activation [16].