Li and colleagues [26] have recently reported that withaferin-A reduced the tumor multiplicity, though not the incidence, of DMBA-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA) promoted mouse skin tumor formation partly by blocking the expression of acetyl CoA carboxylase-1 (ACC1) and the activation of activator protein-1 (AP-1). The gene discussed is ACACA; the disease is neoplasm.