BCL2L1 and cancer: Despite all these insights into deamidation-induced Bcl-xL loss of function and cancer progression, three important arguments add up and highlight that the matter still deserves thriving attention: (1) cells resort to a repair enzyme called isoaspartyl methyltransferase to convert isoAsp into Asp residues, and thus eliminate the isopeptide bond which alters the conformation of proteins.