Of the top 207 transcripts annotated as ‘cell cycle’ by GO analysis (Supplementary Table S5), we focused on nine well-known cell cycle regulators (CCNA2, CCND1, CDK6, CHK1, CHK2, MAPK1, MAP2K1,SKP2, and TFDP1) for further analyses, due to their known functions in cancers. The gene discussed is MAP2K1; the disease is cancer.