Of the top 207 transcripts annotated as ‘cell cycle’ by GO analysis (Supplementary Table S5), we focused on nine well-known cell cycle regulators (CCNA2, CCND1, CDK6, CHK1, CHK2, MAPK1, MAP2K1,SKP2, and TFDP1) for further analyses, due to their known functions in cancers. This evidence concerns the gene SKP2 and cancer.