STAT3 and familial pancreatic carcinoma: In our system, due to the crosstalk between adipocytes and pancreatic cancer cells, we observed an increase in STAT3 phosphorylation in Tyr-705 in cancer cells; as a consequence of IL6/STAT3 signaling pathway activation we observed in MiaPaCa2 cells an increase in WNT5a expression (Figure 8).