To confirm wt-p53 translocation to the mitochondria in various cancer cells, we evaluated the subcellular distribution of p53 and ROS levels in wt-p53 cancer cells (e.g., HCT-116, MDA-MB-231, and HepG 2 cells), mut-p53 cancer cells (e.g., SW480, MCF-7), and normal cells (e.g., L02 cells) after TPA treatment [14]. The gene discussed is TP53; the disease is cancer.