Genes such as APOBEC3G and APOBEC3F seem to play and important role in the immune response in NSCLC, while over-representation of CCL5 (a gene widely studied in other malignancies), CD1D, LAT, TRAT1, IL32 and others, suggest different regulatory activities of T lymphocytes in NSCLC in women compared to men. This evidence concerns the gene APOBEC3F and non-small cell lung carcinoma.