PROS1 and thrombophilia: All 6 had ≥ 1 thrombophilia or hypofibrinolysis: 1 heterozygous for the G20210A prothrombin gene mutation, 1 homozygous for the 4G4G PAI-1 gene mutation, 1 with high factor VIII, 1 with high ACLA IgG, 3 with high homocysteine (1 of whom had MTHFR C677T homozygosity), 2 with low protein C, 2 with low protein S, and 2 with low free protein S, Table 2.