Some evidence suggest that sorafenib can block Raf⁄MEK⁄ERK signaling pathway to inhibit tumor cell proliferation and it can also target the tyrosine kinase receptor vascular endothelial growth factor receptor-2 (VEGFR-2) or platelet-derived growth factor receptor (PDGFR) to produce inhibition of angiogenesis [6–8]. The gene discussed is KDR; the disease is neoplasm.