FOXO1 and ischemic cardiomyopathy: For instance, Benzhi Cai et al. [70], reported that deletion of FOXO1 in heart caused an increment in myocardial Na+ load by augmenting NaV1.5, a principle α subunit of the cardiac sodium ion channel and Na+ channel subunit β3 mRNA and resulted in shortening of QRS complex significantly, proposing that FOXO1 is facilitating the modulation of sodium channel in ischemic cardiomyopathy.