FOXO1 and Hyperglycemia: Li et al., employed FOXO1 KR/KR knock-in mice to mimic the effect of oxidative stress- (or hyperglycemia-) induced FOXO1 deacetylation on atherosclerosis and demonstrated that FOXO1 gain of function in vascular endothelial cells trump its beneficial effects to lower triglycerides and low density lipoprotein cholesterol levels in its counterpart WTD-fed Ldlr-/- mice, suggesting that FOXO1 is involved in primary atherogenic abnormality occurred in the vascular endothelium [114].