FOXO1 and myocardial infarction: The protective role of FOXO1 is further confirmed by Sengupta et al. who observed that in mice with cardiac-specific deficiency of both FOXO1 and FOXO3 the hearts demonstrated lowered systole, enlarged scar development and amplified apoptosis relative to control mice, when subjected to myocardial infarction through surgical ligation of coronary artery [71].