PTRH2 and esophageal squamous cell carcinoma: To further clarify the signaling pathway mediated by Bit1 downregulation, we performed array assay by gene chip, we found that Bit1 downregulation triggered 23 genes downregulation and 16 genes upregulation in EC9706 cells, which was implicated in cell apoptosis, cell adhesion, invasion and metastasis, etc., suggesting Bit1 may be an important regulator in cell invasion and metastasis of ESCC.