There were also increases in other myeloid cells (Gr1+F4/80+CD11b+) recruited to the lung compartment in HFD mice that were not present in significant numbers in naïve lungs, suggesting that diet-induced obesity also enhances the recruitment of subpopulations of macrophages to the injured lung (Fig. 4i). Here, ITGAM is linked to obesity due to melanocortin 4 receptor deficiency.