In clear contrast, lack of SST drastically aggravated tumor incidence in the context of HF diet-induced obesity, in that SST-KO obese mice had marked worsening in DMBA-induced consequences, with higher tumor incidence, multiplicity and hyperplastic lesions than lean SST-KO mice, and with higher tumor incidence than HF diet-fed WT controls. The gene discussed is SST; the disease is obesity due to melanocortin 4 receptor deficiency.