In support of these results, and reinforcing the idea of the effectiveness of HF diet-induced obesity in the FBV/N mice, plasma levels of leptin (likely, the most relevant adipokine associated with the obese status) were higher in mice on a HF diet compared to those on a LF diet, in line with previous studies reporting strong correlation between leptin levels and adiposity [61]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.