To this end, we have examined, for the first time, the impact of treatment with 7, 12 dimethylbenz[α]anthracene (DMBA), an immunosuppressor and a powerful organ-specific laboratory carcinogen, on mammary gland (MG) hyperplasia and tumor formation/progression in the presence or absence of endogenous SST or CORT, using SST knockout (KO) and CORT KO mice under normal and diet-induced obese conditions. Here, CORT is linked to neoplasm.