EDN1 and ovarian cancer: ET-1 induced activation of nuclear factor kappa-light-chain-enhancer of activated B cells, a key mediator in oncogenesis, is dependent on β-arrestin (Cianfrocca et al., 2014), and β-arrestin-1 is an epigenetic regulator of ET-1-induced β-catenin signaling, a critical mechanism for controlling cell division and ovarian cancer progression (Rosanò et al., 2009, 2013b).