Intriguingly, IRAK3 and TBRG4 showed a significant inverse correlation (P < 0.05) with the OS of GBM only when TMZ was used as a covariate (Table 2, highlighted in grey), whereas the expression of CSNK1E was positively associated with GBM prognosis (Table 2, highlighted in grey). This evidence concerns the gene IRAK3 and glioblastoma.