We discovered that chemokines CCL2, CCL4, and CXCL12 are regulated in MSCs in an ARC-dependent manner, their cognate receptors CCR2, CCR5, and CXCR4 were expressed in AML cells, and that inhibition of receptor/ligand interactions blocked AML cell migration. Here, CXCR4 is linked to acute myeloid leukemia.