Concerning the classic lysosomal markers LAMP2 (Figure 4A–4D and Supplementary Figure S7E) and CTSB (Figure 4E–4H and Supplementary Figure S7F) no considerable differences were observed in LAMP2 protein (Figure 4A–4C) and RNA expression (Figure 4D), while slightly higher CTSB protein levels were detected in glioblastoma tumor centers compared to normal CNS tissue and infiltration zones (Supplementary Figure S7F). Here, LAMP2 is linked to neoplasm.