CKM and cancer: The oncolytic virus exerts its intrinsic capacity of oncolysis, CXCL11 expression leads to systemic adaptive antitumor immunity and attraction of cytotoxic T-cells, while the CKM cocktail modulates the TME to one immunologically favorable with CK profile skewing toward attracting Th1/Tc1 cells, enhancing the attraction of activated Tc1/Th1 cells and NK cells, and sustained activity of attracted immune cells to destroy cancer cells in the TME.