CCL5 and neoplasm: In addition to virally-directed expression of Tc1/Th1-attracting CKs, we have recently found that a CK modulation (CKM) drug cocktail including IFN-α, poly I:C, and a cyclooxygenase (COX)-2 inhibitor, could enhance the production of Tc1/Th1-attracting CKs such as CCL5 and CXCL10, greatly reduce the production of CCL22, a CK associated with infiltration of regulatory T cells (Treg) in human tumor tissue explants in vitro [41].