CD4 and neoplasm: We reasoned that OV would induce an acute inflammatory signal in the TME, prime DCs with danger signal along with TAAs and activate tumor antigen-specific adaptive CD4+ and CD8+ T cells in the draining lymph nodes and in circulation; while CKM would modulate the CK microenvironment leading to increased immunostimulatory CKs such as CCL5 and CXCL10, and concurrent reduction of immunosuppressive CKs (CCL22 and CXCL12).