We reasoned that OV would induce an acute inflammatory signal in the TME, prime DCs with danger signal along with TAAs and activate tumor antigen-specific adaptive CD4+ and CD8+ T cells in the draining lymph nodes and in circulation; while CKM would modulate the CK microenvironment leading to increased immunostimulatory CKs such as CCL5 and CXCL10, and concurrent reduction of immunosuppressive CKs (CCL22 and CXCL12). This evidence concerns the gene CXCL10 and neoplasm.