As discussed previously, our prior work demonstrated that a drug cocktail consisting of IFN-α, poly I:C, and Celebrex (a cyclooxygenase (COX)-2 inhibitor), could enhance the production of immunostimulatory CKs (such as CCL5 and CXCL10), and reduce the production of immunosuppressive CK CCL22 (Treg attractant) in human tumor tissue explants in vitro [41]. This evidence concerns the gene CCL22 and neoplasm.