ACVRL1 and neoplasm: Among the analyzed genes, 4 were selected for their significant modulation and biological function and further validated (Table 1): ACVRL1 (Activin A receptor type II-like 1), known to be involved in angiogenesis and tumor growth; FN1 (Fibronectin-1), a master regulator of ECM remodeling and cell-matrix adhesion; ID1 (Inhibitor of DNA binding 1), which promotes cells proliferation and migration; BCL2L1 (BCL-2 like 1), encoding for a well known anti-apoptotic protein.