Trying to unravel which molecules could be involved in the TGF-β pathway modulation in colon cancer chemoresistance, we performed a gene profiling by analyzing 84 TGF-β target genes: chemoresistant colon carcinoma cells that received 5FU showed an up-regulation of 52 out of 84 genes analyzed (Supplementary Figure S4). Here, TGFB1 is linked to colonic neoplasm.