EGFR and lung carcinoma: Based on these findings, we established IL10 knockout mice (Kras4bG12D/IL10−/− and EGFRL858R/IL10−/−) to investigate whether IL10 promotes lung cancer formation, and the following results were observed: IL10 is important for the formation of the microenvironment during lung cancer progression, and IL10 and EGFR produce positive feedback regulation that enhances lung cancer tumorigenesis.