Based on these findings, we established IL10 knockout mice (Kras4bG12D/IL10−/− and EGFRL858R/IL10−/−) to investigate whether IL10 promotes lung cancer formation, and the following results were observed: IL10 is important for the formation of the microenvironment during lung cancer progression, and IL10 and EGFR produce positive feedback regulation that enhances lung cancer tumorigenesis. The gene discussed is IL10; the disease is lung cancer.