We identified seven evmiRNAs (let-7 g-5p, miR-126-3p, miR-130a-3p, miR-146a-5p, miR-150-5p, miR-191-5p, and miR-23a-3p) with 16 experimentally validated mRNA targets (CCR3, CD40, COL1A2, CSF1, CXCL12, CXCL8, CXCR4, IL1F10, IL36A, IL36B, IL36G, IL36RN, IL37, IL6, PDGFB, and VCAM1) that are involved in several CVD-related signaling pathways such as atherosclerosis, cardiac hypertrophy, Toll-like receptor, T-Helper cell differentiation, cytokines mediating communication between immune cells, and inter-communication between innate and adaptive immune cells. The gene discussed is IL36RN; the disease is cardiac hypertrophy.