Lung SPP1 increases in humans with pulmonary fibrosis (Foster et al. 2015; Nau et al. 1997; Pardo et al. 2005) and in mouse (Berman et al. 2004; Miyazaki et al. 1995; Oh et al. 2015; Sabo-Attwood et al. 2011; Takahashi et al. 2001) and rat (Langley et al. 2011; Ma et al. 2012; Mangum et al. 2004) models of pulmonary fibrosis. The gene discussed is SPP1; the disease is pulmonary fibrosis.