Increased SPP1 has been associated with pulmonary fibrosis in humans (Foster et al. 2015; Nau et al. 1997; Pardo et al. 2005) and in animal models (Berman et al. 2004; Langley et al. 2011; Ma et al. 2012; Mangum et al. 2004; Miyazaki et al. 1995, Oh et al. 2015; Sabo-Attwood et al. 2011; Takahashi et al. 2001). Here, SPP1 is linked to pulmonary fibrosis.