SPP1 contributes to human fibrotic lung disease, and increases in SPP1 are associated with pulmonary fibrosis (Foster et al. 2015; Nau et al. 1997; Pardo et al. 2005) and with the development of fibrosis in a number of animal models (Berman et al. 2004; Langley et al. 2011; Ma et al. 2012; Mangum et al. 2004; Miyazaki et al. 1995; Oh et al. 2015; Sabo-Attwood et al. 2011; Takahashi et al. 2001). The gene discussed is SPP1; the disease is pulmonary fibrosis.