For example, a prospective cohort study has found that adolescent females with childhood adversity were more vulnerable to the depressogenic effects of endogenous IL-6 compared with those without childhood adversity.42 On the basis of the current data, females with two hits, sleep disturbance and inflammation, would represent a high-risk group to be prioritized for depression prevention efforts using interventions that target sleep disturbance or inflammation. Here, IL6 is linked to major depressive disorder.