Compared with ACE inhibitor as the reference treatment (Tables 2 and S8), no RAS blocker used in monotherapy and/or combination was associated with a significant reduction in myocardial infarction: ARB (1.07; 95% CrI 0.89–1.28; moderate confidence), ACE inhibitor plus ARB (1.00; 95% CrI 0.78–1.33; moderate confidence), DR inhibitor plus ARB (0.83; 95% CrI 0.52–1.31; low confidence), and DR inhibitor plus ACE inhibitor (1.35; 95% CrI 0.85–2.12; low confidence). This evidence concerns the gene ACE and myocardial infarction.