Compared with ACE inhibitor as the reference treatment (Tables 2 and S8), no RAS blocker used in monotherapy and/or combination was associated with a significant reduction in heart failure hospitalization: ARB (0.99; 95% CrI 0.86–1.12; moderate confidence), ACE inhibitor plus ARB (0.86; 95% CrI 0.73–1.01; moderate confidence), DR inhibitor plus ACE inhibitor (1.06; 95% CrI 0.75–1.45; low confidence), and DR inhibitor plus ARB (0.83; 95% CrI 0.59–1.14; low confidence). This evidence concerns the gene ACE and heart failure.