ACE and Stroke: Compared with ACE inhibitor as the reference treatment (Tables 2 and S8), no RAS blocker used in monotherapy and/or combination was associated with a significant reduction in the incidence of stroke: ARB (1.01; 95% CrI 0.88–1.16; moderate confidence), ACE inhibitor plus ARB (0.88; 95% CrI 0.71–1.08; moderate confidence).