Further, we stratified the combined dichotomized Ki-67 in PT and LN metastases into four subgroups, using median values as cut-off; high Ki-67 in both (termed HH, n = 58, 35%); high Ki-67 in PT and low in LN (termed HL, n = 27, 16%); low Ki-67 in PT and high in LN (termed LH, n = 26, 15%); low Ki-67 in both tumor sites (termed LL, n = 57, 34%) (S3–S6 Figs). This evidence concerns the gene MKI67 and neoplasm.