Originally considered a potential candidate to replace PCV7, a recent study from Australia demonstrated that 19% of NTHi strains isolated from the nasal cavity, nasopharynx and bronchoalveolar lavage fluid from asymptomatic carriage or children with bronchiectasis were missing the hpd genes encoding protein D of NTHi [146]. The gene discussed is DHRS2; the disease is bronchiectasis.