GATA4 is located at chromosome 8p, a chromosomal locus frequently deletedin multiple tumour types such as colorectal and oesophageal cancer (Refs 142, 143).Alternatively GATA4 can be downregulated via epigenetic silencing, such ashypoacetylation of histones H3 and H4 (Ref. The gene discussed is GATA4; the disease is carcinoma of esophagus.