8). Mice harbouring a knock-in mutation that abrogates the interaction withFOG-cofactors (GATA4Ki/Ki) lack coronary vessels (Ref. 59). In addition, murine GATA4 regulates cardiacangiogenesis by inducing angiogenic factors such as VEGF, facilitating compensationfollowing injury (Ref. 60). Yamak et al. havesuggested that GATA4 and Cyclin D2 are part of a forward reinforcing loop in which CyclinD2 feeds back to enhance cardiogenic activity of GATA4 through direct interaction.GATA4 mutations that abrogate Cyclin D2 interactions are associatedwith human CHD (Ref. 61). The gene discussed is CCND2; the disease is coronary artery disorder.