TP53 and astrocytoma (excluding glioblastoma): 136). GATA6 wasidentified in a mouse astrocytoma model as a novel tumour suppressor gene. Knockdown ofGATA6 expression in RasV12 or p53−/− astrocytes led toacceleration of tumourigenesis. Mutations of GATA6 occur during malignantprogression of murine and human astrocytomas (Ref. 135).