The only GATA1 mutationreported in hereditary X-linked thrombocytopenia with thalassemia is the missense mutationR216Q which is located in the DNA binding surface of the GATA1 N-terminal zinc finger andresults in reduced DNA binding rather than affecting GATA1–FOG1 interaction (Ref. The gene discussed is GATA1; the disease is hereditary thrombocytopenia with normal platelets.