Niemann–Pick type C (NPC) is a neurodegenerative lysosomal storage disorder1 associated with defects in lysosomal calcium homeostasis and lipid trafficking.2 It is caused by mutations in the NPC1 or NPC2 genes.1 The accumulation of unesterified cholesterol and multiple sphingolipids in the late endosomal/lysosomal system causes neurological and visceral symptoms. The gene discussed is NPC1; the disease is nasopharyngeal carcinoma.