NPC1 and Lipid storage disease: This mechanism becomes more obvious in the defence against S. typhimurium compared with AIEC since S. typhimurium is a facultative intracellular pathogen and clearance from the host strongly depends on autophagy.52, 53 The described immune dysfunction extents the role of NPC1 for autophagy beyond hepatic or neuronal cell defects with lipid storage disease.35, 54