PXN and breast cancer: In addition, transfection of Xcad-11-EGFP into HeLa (cervical cancer cells), MCF-7 (breast cancer cells) and murine NIH 3T3 fibroblasts revealed Xcad-11 localization to peripheral FA, where it co-localized with paxillin and F-actin (Fig. 1d; Supplementary Fig. 2).