Its most severe form, AME, can be rescued by renal transplantation,8,29 suggesting that high blood pressure follows the kidney.9 However, 11βHSD2 is also expressed in the brain,17 restricted to a subset of neurons in the NTS in the adult mouse.20 We used a Cre-Lox strategy to conditionally delete Hsd11b2 in the brain, reducing expression in the NTS by >90%. This evidence concerns the gene HSD11B2 and blood pressure trait.