CD4 and infection: However, the observation of progression to a CD4+ T-cell count of <350 cells/mm3 within 6 months of infection in >80% of the HLA-B*58:02–positive placebo recipients, together with a viral set point of 5.1 log10 copies/mL in these subjects, is consistent with rapid progression observed in natural infection in HLA-B*58:02–positive individuals [6, 30].